I'm not sure that Republicans will have any success at this:
With a big new majority in the House, Republicans will have little trouble passing whatever they want – including a full repeal of the health care reform law. But Republicans don't have a majority in the Senate, so even modest changes to the law will require the help of centrist Democrats – or at least scared ones.
Manchin is the Republicans' top target – because he campaigned against part of the law, and because he'll have to face the voters again in 2012 if he wants to serve a full term.