It makes sense for Rudy Giuliani to predict a Clinton-Obama ticket. Not because there'll be a Clinton-Obama ticket -- Clinton is more likely to add a red-state white dude to the ticket in an attempt to reduce incorrect public perceptions that she's a liberal Democrat. Even accounting for the greater probability of Hillary winning the primary, an Edwards-Obama ticket is more likely.
Giuliani is doing this because the case for him is supposed to be that he has the best chance to keep Democrats from winning in a landslide come 2008. Assuming that Scott is right in the Lemieux-Yglesias debate over James Dobson's contingency plans, that's probably right. And that's why Giuliani is opening his mouth and making noises that make Republicans think about a general election, and about how much they hate Hillary. Anything that makes them think about the general election and not about his checkered ideological and personal past advances his cause. (And if it increases the likelihood that he'll face the two Democrats who beat him by 5% rather than 9%, all the better for him!)